What is Naproxen? A Complete Guide to This Pain Relief Medication

March 12, 2025

Introduction

Naproxen is a widely used nonsteroidal anti-inflammatory drug (NSAID) that helps relieve pain, inflammation, and stiffness caused by conditions such as arthritis, back pain, and menstrual cramps. Known for its long-lasting pain relief, it is available both over the counter (OTC) and on prescription in the UK.

But how does Naproxen work? Is it stronger than ibuprofen? Can you take it every day? In this guide, we’ll cover everything you need to know, including its dosage, side effects, and availability in the UK.

How Does Naproxen Work?

Naproxen belongs to the NSAID group of medicines, which work by reducing inflammation and blocking pain signals. It does this by inhibiting an enzyme called cyclooxygenase (COX), which produces prostaglandins—chemicals responsible for pain, swelling, and fever.

Because of its longer-lasting effects (up to 12 hours per dose), Naproxen is preferred over ibuprofen for chronic pain conditions like arthritis.

What is Naproxen Used For?

Naproxen is commonly used for various types of pain, including:

1. Arthritis & Joint Pain

Rheumatoid arthritis
Osteoarthritis
Gout (reduces inflammation in flare-ups)

2. Musculoskeletal Pain

Back pain
Sciatica
Sprains, strains, and sports injuries

3. Menstrual Cramps (Dysmenorrhoea)

More effective than ibuprofen for severe period pain

4. Migraines & Headaches

Sometimes used to relieve moderate migraines

5. Post-Surgery or Injury Recovery

Reduces swelling and speeds up healing

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Types & Strengths of Naproxen

Prescription vs Over-the-Counter (OTC) Naproxen

In the UK, Naproxen is available in different strengths:

OTC Naproxen (220mg per tablet) – Sold as feminax ultra for period pain.
Prescription Naproxen (250mg or 500mg tablets) – Used for arthritis, back pain, and stronger pain relief.

It also comes in liquid and enteric-coated (slow-release) forms.

Prescription Naproxen (250mg or 500mg tablets) – Used for arthritis, back pain, and stronger pain relief. You can buy Naproxen 250mg or Naproxen 500mg here.

How to Take Naproxen Safely

Recommended Dosage: Usually 250mg or 500mg every 8-12 hours, depending on severity.
Should I take it with food? – Yes, always take Naproxen with food or milk to protect your stomach.
How long does it take to work? – Pain relief typically starts within 1 hour and lasts 8-12 hours.

Side Effects & Risks

Like all NSAIDs, Naproxen has potential side effects.

Common Side Effects:

Indigestion & heartburn
Nausea & dizziness
Headaches

Serious Risks (Less Common):

Stomach ulcers & bleeding (especially with long-term use)
Kidney damage (especially in elderly or dehydrated individuals)
Increased risk of heart problems with prolonged use

💡 Tip: To reduce side effects, always take Naproxen with food and avoid excessive alcohol.

Who Should Avoid Naproxen?

Naproxen may not be suitable if you:

Have a history of stomach ulcers
Have kidney or heart disease
Are pregnant (especially in the 3rd trimester)
Take blood thinners (warfarin) or steroids

⚠️ Drug Interactions: Avoid taking Naproxen with other NSAIDs (e.g., ibuprofen, aspirin) as this increases the risk of side effects.

Naproxen vs Other Painkillers

Naproxen vs Ibuprofen – Which is Better?

Feature	Naproxen	Ibuprofen
Duration	8-12 hours	4-6 hours
Strength	Stronger	Weaker
Best for	Chronic pain (arthritis, period pain)	Mild pain (headaches, muscle pain)
Side effects	Higher risk of stomach issues	Milder on stomach

💡 Verdict: Naproxen is better for long-lasting pain relief, while ibuprofen is gentler on the stomach.

Can You Buy Naproxen Over the Counter in the UK?

Yes! In the UK, you can buy low-dose Naproxen (220mg) OTC, mainly for period pain. However, for conditions like arthritis or back pain, a prescription is required.

💡 Where to buy: Naproxen is available from Online Chemist.

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FAQs About Naproxen

1. Can I drink alcohol while taking Naproxen?

Yes, but too much alcohol may irritate your stomach and increase the risk of ulcers.

2. How long can I take Naproxen for?

Short-term use (a few days to weeks) is safe. Long-term use should be monitored by a doctor.

3. Can I take Naproxen with other painkillers?

YES – Paracetamol is safe to take with Naproxen.
NO – Avoid ibuprofen or aspirin (increases risk of side effects).

4. Does Naproxen make you sleepy?

Naproxen can cause drowsiness in some people, so avoid driving until you know how it affects you.

Conclusion

Naproxen is an effective, long-lasting pain reliever used for arthritis, back pain, menstrual pain, and inflammation. While it’s stronger than ibuprofen, it carries higher risks for stomach issues.

Available as: Prescription (250mg, 500mg) or OTC (220mg for period pain)
Best for: Chronic pain and inflammation
Take with food to reduce side effects

If you’re looking for a stronger alternative to ibuprofen, Naproxen may be the right choice for you.

References

1. NHS (National Health Service – UK) – 📌 Naproxen: Uses, Side Effects, and Dosage
2. Medicines and Healthcare products Regulatory Agency (MHRA – UK) – 📌 Official Naproxen Patient Leaflet (Dosage, Warnings, & Contraindications)

3. British National Formulary (BNF) – Naproxen – 📌 Clinical Guidelines & Prescribing Information
4. Arthritis UK – Naproxen for Joint Pain – 📌 How Naproxen Helps with Arthritis & Inflammation
5. Mayo Clinic – Naproxen Overview – 📌 Comparison with Other Painkillers & Long-term Risks

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